What is oxymetazoline (nasal spray) used for? 

Oxymetazoline is a medication which is called a “vasoconstrictor”. When oxymetazoline is used as nasal spray, it can act to temporarily reduce congestion. 

What's the difference between oxymetazoline (Afrin) nasal spray and phenylephrine nasal spray?

Oxymetazoline (Afrin) nasal spray is approved for children greater than or equal to 6 years of age. Phenylephrine nasal spray can be used in children 2 years of age and greater. Phenylephrine can be used in children less than 2 years of age, but it is recommended to talk to your child’s primary care physician before doing so. 

What are the most common side effects seen with oxymetazoline? 

• Nasal discharge

• Nasal stinging

• Nasal burning

• Sneezing

• Rebound nasal congestion 

  • If oxymetazoline is used too frequently or for too long, it can cause nasal congestion to return or worsen. 

Contraindications & Warnings

Oxymetazoline (nasal spray) should not be taken if your child has had an anaphylactic reaction (hives or swelling of the tongue) to oxymetazoline previously. 

Oxymetazoline nasal spray should not be taken for greater than 3 days. 

Always consult with your child’s doctor about taking oxymetazoline to see if it is an appropriate option. 

Breast feeding considerations 

• Oxymetazoline can be present in breast milk if being taken by the mother. 

• There are little to no reports of mothers taking oxymetazoline nasal spray while breastfeeding, and therefore the effect on the infant is unknown.

The information in this database regarding prescription drugs is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interaction or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate, or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. See disclaimer.